摘要：AbstractDifferent applications can be represented as systems controlled by pulse inputs, which are of short duration within the sampling period. Despite the vast development of control strategies for discrete systems and some others for impulsive ones, the generalization for pulse-controlled systems has not been widely studied. Here, an offset-free control approach for pulse systems is presented for the first time. This strategy aims to compensate for the offset problem caused by a plant-model mismatch or constant disturbances. It consists of an augmented model with an integrating state, an estimator to capture the mismatch, and a model predictive control (MPC) formulation that includes the estimated mismatch in the prediction model and the target calculation to achieve the objective. In addition, the strategy is tested for type 1 diabetes treatment, where physiological variations constantly change the insulin requirements of patients which, if not compensated, can lead hypoglycemia and hyperglycemia episodes. The developed method is evaluated in 10 adult virtual patients of the UVA/padova Simulator and it is compared with a zone MPC (ZMPC). Satisfactory results were obtained by achieving a time in normoglycemia range of 93% in a simulation scenario without meal announcement and 30% of parameter variations.
关键词：KeywordsControl by pulsesmodel predictive controloffset-free controltype 1 diabetes mellitusartificial pancreas
