摘要:AbstractManufacturing systems’ efficiency depends on the proper assignment of orders to resources. Due to existing interdependencies, the integrated consideration of production, inventory and delivery processes can improve the overall manufacturing performance. However, the integration can result in high complexity and stochasticity. Thus, the three areas are rarely addressed together. Thereof, this paper proposes an integrated simulation-based optimization method to cope with uncertainty and complexity. The proposed approach was compared to a benchmark approach and the obtained results show that the first is able to handle the complexity and stochasticity of real-world manufacturing systems, surpassing the performance of the latter.