摘要：AbstractAll drug regulatory paradigms are dependent on the hemodynamic system as it serves to distribute and clear the drug in/from the body. In this work, stabilization of hemodynamic variables within the context of maintaining general anesthesia conditions is presented. Several methods for robust control are employed, all based on the emerging fractional order control algorithm with inherent robustness to gain and phase margin variations. These are important due to the inter- and intra- patient variability at hand. The results indicate the great suitability of fractional order control as a substantially robust algorithm which can be used in combination with regulatory schemes for better closed loop performance. The challenges of the hemodynamic system under analysis here is the high coupling (multivariable system) with delay-dominant dynamics. Additionally, disturbance from the anesthesia-regulatory system and realistic surgical stimulation profiles are incorporated to complete the analysis. The results support the claims.
关键词：Keywordshemodynamic regulationanesthesia regulationdelay dominant dynamicsmultivariable controlfractional order control
