摘要:AbstractThis paper deals with the setpoint control of Chemical Reaction Networks (CRNs) in the presence of disturbances. The addressed control problem is traced back to the output feedback-based stabilization of passive systems. First, the passivity properties of complex balanced CRNs are discussed. Second, it is shown that, by combining the kinetic feedback based control with the passivity theory-based output feedback approach, arbitrary disturbance attenuation in controlled CRNs can be achieved. A case study is provided to demonstrate the applicability of the proposed control design approach.