标题：Gastric histopathological features after the administration of omeprazole, amoxicillin, and clarithromycin in gastritis Helicobacter pylori rat model
期刊名称：Journal of Advanced Veterinary and Animal Research
印刷版ISSN：2311-7710
出版年度：2021
卷号：8
期号：1
页码：158-163
DOI：10.5455/javar.2021.h498
语种：English
出版社：Bangladesh Agricultural University, Faculty of Veterinary Science
摘要：Objective:
This research work aimed to assess the histopathological features and degree of gastritis severity in a rat model, induced by
Helicobacter pylori infection after administering omeprazole, amoxicillin, and clarithromycin as the standard first-line eradication regimen.
Material and Methods:
Twenty-one male rats were adapted for 7 days and randomly divided into three equal groups. Group 1 was considered a negative control. Group 2 and Group 3 were treated as
H. pylori-inoculated groups. Group 2 was set as a positive control. Group 3 was administered omeprazole, amoxicillin, and clarithromycin as a first-line eradication regimen. Gastric histopathological examination was conducted. The difference in the severity of gastritis among the groups was examined using the one-way analysis of variance test. The significance was determined to be
p < 0.05.
Results:
Gastritis was found in all inoculated groups. The severity of gastritis was highest in Group 2 (
p < 0.05). We could see a refinement in gastritis severity after administering omeprazole, amoxicillin, and clarithromycin as a first-line eradication regimen (Group 3
vs. Group 2;
p <0.05).
Conclusion:
Gastritis, induced by the
H. pylori rat model, was found in all inoculated groups. There was a refinement in the degree of gastritis severity after the administration of omeprazole, amoxicillin, and clarithromycin as a first-line eradication regimen.
