出版社：Universita degli Studi di Modena e Reggio Emilia
摘要：Autophagy is a well-conserved intracellular degradation system in which cytoplasmic components and organelles are recycled by double- membraned autophagosomes that engulf them and eventually fuse with lysosomes (Levin et al., 2011). Because most of the genes involved in autophagy are conserved from yeast to invertebrates and mammals, and genetic manipulations can easily be performed in Drosophila in vivo, Drosophila is an ideal model system for studying the function of autophagy in whole animals. Studies of autophagy- related gene mutants revealed the importance of autophagic functions in larval midgut cell death during morphogenesis (Denton et al., 2009), and hematopoiesis in larvae (Shravage et al., 2013). In addition to its essential functions in development, emerging evidence indicates that autophagy functions against invasion of host cells by pathogens such as intracellular bacteria, viruses, and protozoa (Yano and Kurata, 2011). Here, we summarize and provide insight into the functions of autophagy in innate immunity in invertebrates.
