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  • 标题:Antifungal peptides in marine invertebrates
  • 本地全文:下载
  • 作者:N Fusetani
  • 期刊名称:Invertebrate Survival Journal
  • 电子版ISSN:1824-307X
  • 出版年度:2010
  • 卷号:7
  • 期号:1
  • 页码:53-66
  • 语种:English
  • 出版社:Universita degli Studi di Modena e Reggio Emilia
  • 摘要:A majority of terrestrial and marine organisms use to fend off a wide range of microorganisms, including bacteria and fungi by employing “antimicrobial peptides (AMPs)” that are ribosomally synthesized from proteinogenic amino acids. AMPs are a primary component of innate immune mechanisms in marine invertebrates. In contrast, marine sponges seem to contain no AMPs, but often contain nonribosomal peptides consisting of unusual amino acids that exhibit potent cytotoxic and antifungal activity. Most of these peptides are considered to be of symbiotic bacterial origin. Similarly opisthobranch molluscs sequester unusual bioactive nonribosomal peptides from their prey organisms, cyanobacteria. However, roles of these peptides are unknown.
  • 关键词:nonribosomal peptide;antifungal activity;antimicrobial peptide;innate immunity;marine invertebrate
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