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  • 标题:A unified resource and configurable model of the synapse proteome and its role in disease
  • 本地全文:下载
  • 作者:Oksana Sorokina ; Colin Mclean ; Mike D. R. Croning
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2021
  • 卷号:11
  • DOI:10.1038/s41598-021-88945-7
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein–protein interactions and functional metadata to build a network resource that reveals the shared and unique protein components that underpin multiple disorders. All the data are provided in a flexible and accessible format to encourage custom use.
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