摘要：Diabetes has turned out to be pandemic towards the end of the century; unfortunately there are many people who are still unaware of the fact that they are having diabetes even if they have already developed various complications related to it. Patients with long duration of Type 2 Diabetes Mellitus have a significantly increased risk of developing related complications. This ignorance is due to similar manifestations for two related health problems like that of heart problem which may or may not be related to diabetes. Finding genetic variants in genes is a pretty good method for assessment of the risk for type 2 diabetes mellitus and the complications related to it. These genetic predisposing factors can foretell the susceptibility of a person to the disease or become the reason behind diabetes in the person. The present case control study intends to associate the reported single nucleotide polymorphisms in seven genes viz. Calpain10 (CAPN10), Adiponectin (ADIPOQ), Apolipoprotein C-III (APOC III)], Angiotensinogen (AGT), Apolipoprotein E (APOE) and Toll-Like Receptor 4(TLR4) genes as risk factors for Type 2 Diabetes and its related Complications in the discrete diabetic population of Andhra Pradesh and Telangana states in India. The results showed the association some of the single nucleotide polymorphisms in the candidate genes which increased the risk of development of type 2 diabetes mellitus and progression in the form of complications.The results showed the presence of new Single Nucleotide Polymorphism in the Type 2 Diabetes cases. Further extension of analyses work on a larger sample size is to be undertaken in our study population.
关键词：Type 2 diabetes mellitus (T2DM); complications; predisposing factors; genes; new Single Nucleotide Polymorphisms (SNPs); genetic variants
