摘要：Immunosuppressive treatment with mesenchymal stromal (stem) cells (MSCs) has been performed in many human transplantation settings with the goal to prevent rejection. The therapeutic potential of MSCs has also been explored in a broad spectrum of applications including the treatment of autoimmune diseases. As the immunomodulatory function of MSCs is a multifactorial process, it is important to occasionally review the precise molecular mechanisms/modalities and insights into how they are orchestrated and deployed in clinical settings. This article aimed to review the mechanisms of the immunosuppressive activities of MSCs from a molecular (modality) perspective, with an emphasis on recent reports published between 2014 and mid 2016. The article highlights the subtle differences due to cell type, timing, and types of priming that could lead to better quality control and pre-enhancement of MSCs to optimize their therapeutic potential.
