摘要：Background and aim: Recent research has shown that non high-density lipoprotein cholesterol (non-HDL-C), a lipid measure that includes cholesterol of all potentially atherogenic lipoproteins, is a useful marker of the risk of cardiovascular disease. On the other hand, associations of non-HDL-C with dyslipidemia and metabolic syndrome (MetS) in healthy general population appear to be of importance in primary prevention and management of diseases. We here aim to analyze the correlation of non-HDL-C and Friedewald-estimated low density lipoprotein-cholesterol (LDL-C) with several routine metrics including body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose, hemoglobin A1c (HbA1c), triglyceride, and uric acid for a healthy adult population in Japan. Methods: Pearson correlation analysis was conducted using a dataset of 34,303 persons (17,103 men and 17,200 women) without known cardiovascular diseases who underwent health checkups under fasting state from 1998 to 2006. LDL-C was estimated using Friedewald formula, and non-HDL-C was calculated as total cholesterol minus HDL-C value. Results: The correlations of non-HDL-C with cardiometabolic markers (BMI, SBP, DBP, fasting plasma glucose, HbA1c, triglyceride, and uric acid) were stronger than Friedewald-estimated LDL-C for subjects with a wide range of triglycerides values. Women generally showed stronger correlations than men. In receiver operating characteristic analysis, non-HDL-C showed greater areas under the curve than Friedwald-estimated LDL-C (0.689 vs. 0.556, P P Conclusions: Regardless of triglyceride levels of subjects, non-HDL-C showed stronger correlations with routine markers like triglycerides, blood pressures, fasting plasma glucose and uric acid compared to Friedewald-estimated LDL-C for healthy adults in Japan. For health checkup routines, especially for those intended for prevention of MetS and pre-MetS states, non-HDL-C may be a better metric than Friedewald-estimated LDL-C.
关键词：non-HDL-C; LDL-C; MetS; Health checkup routine markers
