期刊名称：General Internal Medicine and Clinical Innovations
电子版ISSN：2397-5237
出版年度：2016
卷号：1
期号：6
页码：1-4
DOI：10.15761-GIMCI.1000132
语种：English
出版社：Open Access Text
摘要：Vasohibin-1 (VASH1), an endothelium-derived angiogenesis inhibitor, has unique functions of promoting stress tolerance and survival of endothelial cells. The expression of VASH1 decreases with aging, and this reduction may worsen vascular diseases such as diabetic vascular complications and atherosclerosis. Here we determined the plasma level of VASH1 in normal volunteers and patients with peripheral vascular disease. The plasma VASH1 concentration tended to be higher in males than in females in the normal volunteer group, and acute exercise did not alter this level, indicating that this concentration remained steady. Patients with peripheral vascular disease were older, and their plasma VASH1 concentrations tended to be lower. When those patients received physical exercise therapy over a 6-month period, their plasma VASH1 level increased significantly. This is the first demonstration that physical exercise can modulate the plasma VASH1 level in elderly patients with peripheral vascular disease.
