期刊名称：General Internal Medicine and Clinical Innovations
电子版ISSN：2397-5237
出版年度：2020
卷号：5
期号：1
页码：1-6
DOI：10.15761-GIMCI.1000187
语种：English
出版社：Open Access Text
摘要：The demand for novel melanin synthesis inhibitors is increasing due to the weak effectiveness and unwanted side effects. Thus, marine algae have been studied as sources of inhibitors of melanin synthesis, but it is still unclear whether they will be effective in in vivo. In this study, we investigated whether marine algal phlorotannins including phloroglucinol (PG), ekcol (EK), and dieckol (DK) from Ecklonia cava inhibit melanin synthesis in zebrafish embryos. PG, EK, and DK treatment were found to inhibit melanin synthesis in zebrafish embryos as similar to arbutin, used as a positive control. Interestingly, PG, EK, and DK treatment showed no toxicity, whereas arbutin treatment showed toxicity for long-term exposure. As well, mRNA expression of pro-inflammatory cytokines, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF- α), and cyclooxygenase-2 (COX-2) were increased in arbutin treatment, whereas, the mRNA expression were not altered in PG, EK, and DK treatment by long-tern exposure. These findings suggest that PG, EK, and DK from E.cava inhibit melanin synthesis similar to arbutin without inflammatory toxicity. PG, EK, and DK from E. cava could be a potential prevention and/or therapeutic ingredients for hyperpigmentation.
