摘要：The study of biological activity of extracts from roots and rhizomes of male fernDryopteris filix-maswas carried out in experiments with soil nematodeCaenorhabditis elegans. The toxicity of extracts ofD. filix-masroots and rhizomes obtained by different methods varied over a wide range. Crude extract of male fern roots and rhizomes in concentration range 62.5–250 µg/ml had a weak toxic action onC. elegansorganism by inducing death of 26.0–43.3% nematodes. The toxicity of relatively high concentrations (500 and 250 µg/ml) of water-ethanolic extracts might be compared with such of crude extract in concentrations 62.5–250 µg/ml. Biological activity of filicinic acids ethers was found very high: concentrations of crude extract ofD. filix-masroots and rhizomes and concentrations of filicinic acids ethers with similar toxicity forC. elegansorganism were 40-fold different. Substances isolated fromD. filix-masroots and rhizomes have nematicidal activity and may be used for development of drugs to treat helminthiasis of humans and animals.
