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  • 标题:Decreased neural activity and neural connectivity while performing a set-shifting task after inhibiting repetitive transcranial magnetic stimulation on the left dorsal prefrontal cortex
  • 本地全文:下载
  • 作者:Niels J H M Gerrits ; Odile A van den Heuvel ; Ysbrand D van der Werf
  • 期刊名称:BMC Neuroscience
  • 印刷版ISSN:1471-2202
  • 电子版ISSN:1471-2202
  • 出版年度:2015
  • 卷号:16
  • 期号:1
  • 页码:1
  • DOI:10.1186/s12868-015-0181-3
  • 语种:English
  • 出版社:BioMed Central
  • 摘要:Background Sub-optimal functioning of the dorsal prefrontal cortex (PFC) is associated with executive dysfunction, such as set-shifting deficits, in neurological and psychiatric disorders. We tested this hypothesis by investigating the effect of low-frequency ‘inhibiting’ off-line repetitive transcranial magnetic stimulation (rTMS) on the left dorsal prefrontal cortex on behavioural performance, neural activity, and network connectivity during the performance of a set-shifting paradigm in healthy elderly (mean age 50+). Results Behaviorally, we found a group-by-session interaction for errors on set-shift trials, although post hoc tests did not yield significant findings. In addition, the verum group, when compared with the sham group, displayed reduced task-related activity in the left temporal gyrus, and reduced task-related connectivity of the left PFC with the left postcentral gyrus and posterior insula. Conclusion These results show that low-frequency off-line rTMS on the left dorsal PFC resulted in reduced task-related activity and network connectivity, which was accompanied by a subtle behavioural effect, thereby further corroborating the importance of an optimally functioning PFC in set-shifting.
  • 关键词:Key-words ; Set-shifting ; Low-frequency repetitive transcranial magnetic stimulation ; Functional magnetic resonance imaging ; Prefrontal cortex ; Connectivity
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