摘要：Staphylococcus epidermidis (
S. epidermidis) ATCC 12228 was incubated with 2% polyethylene glycol (PEG)-8 Laurate to yield electricity which was measured by a voltage difference between electrodes. Production of electron was validated by a Ferrozine assay. The anti-
Cutibacterium acnes (
C. acnes) activity of electrogenic
S. epidermidis was assessed in vitro and in vivo. The voltage change (~ 4.4 mV) reached a peak 60 min after pipetting
S. epidermidis plus 2% PEG-8 Laurate onto anodes. The electricity produced by
S. epidermidis caused significant growth attenuation and cell lysis of
C. acnes. Intradermal injection of
C. acnes and
S. epidermidis plus PEG-8 Laurate into the mouse ear considerably suppressed the growth of
C. acnes. This suppressive effect was noticeably reversed when cyclophilin A of
S. epidermidis was inhibited, indicating the essential role of cyclophilin A in electricity production of
S. epidermidis against C
. acnes. In summary, we demonstrate for the first time that skin
S. epidermidis, in the presence of PEG-8 Laurate, can mediate cyclophilin A to elicit an electrical current that has anti-
C. acnes effects. Electricity generated by
S. epidermidis may confer immediate innate immunity in acne lesions to rein in the overgrowth of
C. acnes at the onset of acne vulgaris.
