摘要:This manuscript focuses on the SARS-CoV-2 outbreak in the Czech Republic and its impact on economic and social sustainability in this country. The topic of this manuscript is the topical issue of how to manage the outbreak of this infectious disease and thereby reduce any disruption to economic and social sustainability. The aim of the authors was to identify serious risks and to propose priority measures that can lead to their significant mitigation. A modified semi-quantitative three-component probability method Pj, consequences Cj and opinion of evaluators OEj were used to assess active risks. The manuscript also presents risk analysis and risk management and the construction of developmental regression models. The manuscript presents a proposal for preventive measures to mitigate risks in the period of the third wave of the occurrence and spread of the coronavirus. Most of the proposed preventive measures were based on brainstorming of the views and experience of the implementation team. Consultation with and materials by experts in the field of developmental biology, parasitology, epidemiology and virology were also used. As such, this survey provides lessons for other cities and regions involved in coping with COVID-19 infection and implementing the policy of a positive and timely return to work.