摘要：SummaryThe capacity to distinguish comparable experiences is fundamental for the recall of similar memories and has been proposed to require pattern separation in the dentate gyrus (DG). However, the cellular mechanisms by which mature granule cells (GCs) of the DG accomplish this function are poorly characterized. Here, we show that Kv4.2 channels selectively modulate the excitability of medial dendrites of dentate GCs. These dendrites are targeted by the medial entorhinal cortex, the main source of spatial inputs to the DG. Accordingly, we found that the spatial pattern separation capability of animals lacking the Kv4.2 channel is significantly impaired. This points to the role of intrinsic excitability in supporting the mnemonic function of the dentate and to the Kv4.2 channel as a candidate substrate promoting spatial pattern separation.Graphical abstractDisplay OmittedHighlights•The Kv4.2 channel decreases the excitability of medial dendrite synapses in GCs•The Kv4.2 channel dampens the amplitude of bAPs in medial dendrites of GCs•Intrinsic plasticity of medial perforant path DG is occluded in the absence of Kv4.2•The Kv4.2 knockout results in a specific impairment of spatial pattern separationBiological sciences; Neuroscience; Cellular neuroscience
