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  • 标题:Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes
  • 本地全文:下载
  • 作者:Hyeonhui Kim ; Minki Kim ; Sun-Kyoung Im
  • 期刊名称:Laboratory Animal Research
  • 印刷版ISSN:1738-6055
  • 电子版ISSN:2233-7660
  • 出版年度:2018
  • 卷号:34
  • 期号:4
  • 页码:147-159
  • DOI:10.5625/lar.2018.34.4.147
  • 语种:English
  • 出版社:BioMed Central Ltd.
  • 摘要:Genetically engineered mouse models are commonly preferred for studying the human disease due to genetic and pathophysiological similarities between mice and humans. In particular, Cre-loxP system is widely used as an integral experimental tool for generating the conditional. This system has enabled researchers to investigate genes of interest in a tissue/cell (spatial control) and/or time (temporal control) specific manner. A various tissue-specific Cre-driver mouse lines have been generated to date, and new Cre lines are still being developed. This review provides a brief overview of Cre-loxP system and a few commonly used promoters for expression of tissue-specific Cre recombinase. Also, we finally introduce some available links to the Web sites that provides detailed information about Cre mouse lines including their characterization.
  • 关键词:Cre-loxP system;tissue specific promoter;Cre portal sites
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