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  • 标题:Impaired liver regeneration and lipid homeostasis in CCl 4 treated WDR13 deficient mice
  • 本地全文:下载
  • 作者:Arun Prakash Mishra ; Archana B. Siva ; Chandrashekaran Gurunathan
  • 期刊名称:Laboratory Animal Research
  • 印刷版ISSN:1738-6055
  • 电子版ISSN:2233-7660
  • 出版年度:2020
  • 卷号:36
  • 期号:1
  • 页码:1-10
  • DOI:10.1186/s42826-020-00076-8
  • 语种:English
  • 出版社:BioMed Central Ltd.
  • 摘要:WDR13 - a WD repeat protein, is abundant in pancreas, liver, ovary and testis. Absence of this protein in mice has been seen to be associated with pancreatic β-cell proliferation, hyperinsulinemia and age dependent mild obesity. Previously, we have reported that the absence of WDR13 in diabetic Leprdb/db mice helps in amelioration of fatty liver phenotype along with diabetes and systemic inflammation. This intrigued us to study direct liver injury and hepatic regeneration in Wdr13−/0 mice using hepatotoxin CCl4. In the present study we report slower hepatic regeneration in Wdr13−/0 mice as compared to their wild type littermates after CCl4 administration. Interestingly, during the regeneration phase, hepatic hypertriglyceridemia was observed in Wdr13−/0 mice. Further analyses revealed an upregulation of PPAR pathway in the liver of CCl4- administered Wdr13−/0 mice, causing de novo lipogenesis. The slower hepatic regeneration observed in CCl4 administered Wdr13−/0 mice, may be linked to liver hypertriglyceridemia because of activation of PPAR pathway.
  • 关键词:Fatty liver;PPARg;Hepatosteatosis;Hypertriglyceridemia;Hepatotoxin
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