Sorption coefficients were evaluated for pyroxasulfone, s-metolachlor, and dimethenamid-p across 25 soil types with different chemical and physical properties to better understand how soil properties influence the binding of pyroxasulfone in different soils. Sorption coefficients were determined using a batch equilibrium method to evaluate relative differences in binding among the three herbicides. Based on water solubility values, we would have expected the relative order of binding to be dimethenamid-p (1450 mg L⁻¹ at 20°C), s-metolachlor (530 mg L⁻¹ at 20°C), and pyroxasulfone (3.49 mg L⁻¹ at 20°C) in order of increasing binding. However, when sorption coefficients were calculated, we observed the order of pyroxasulfone = dimethenamid-p