标题：Viral load is associated with abnormal serum levels of micronutrients and glutathione and glutathione-dependent enzymes in genotype 3 {HCV} patients
摘要：Abstract Background Oxidative stress in hepatitis C patients has been linked to hepatitis C virus. We verified this assumption in {HCV} genotype 3 patients by detecting the relationship between viral load and certain specific oxidative stress markers like Cu, Mn, Fe, Se, Zn and glutathione and glutathione-dependent enzymes. Method Subjects (n = 200, average age 24 years) with quantitative {HCV} {RNA} polymerase chain reaction-proven genotype 3 hepatitis C were simultaneously evaluated. Cu, Mn, Fe, Se and Zn serum levels were by using atomic absorption spectrophotometer. Internationally accepted methods were used for viral load quantification of glutathione, {GR} and Gpx serum levels. Result There was a significant correlation between {HCV} viral load and studied parameters. With the increase of viral load from mild group (200,000–1,000,000 copies/ml) to severe group (5,000,000–25,000,000 copies/ml) the serum levels of Cu, Mn, Zn, and Fe and glutathione reductase were found to be abnormally high. However, in severe viral load group serum concentration of Se and glutathione was less than the healthy controls. Conclusion As a significant correlation was detected between the study parameters in genotype 3 {HCV} patients, it is concluded that the studied micronutrients and glutathione and glutathione-dependent enzymes are the biomolecular targets of {HCV} to induce oxidative stress. General significance Constant monitoring and regulation of the recommended biomolecular targets of {HCV} can improve the plight of more than 170 million patients suffering from hepatitis C virus around the globe.
关键词：Hepatitis C viral load; Glutathione; Glutathione reductase; Glutathione peroxidase; Micronutrients
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