摘要：Abstract Plasma high density lipoprotein cholesterol (HDL) comprises a heterogeneous family of lipoprotein species, differing in surface charge, size and lipid and protein compositions. While {HDL} cholesterol (C) mass is a strong, graded and coherent biomarker of cardiovascular risk, genetic and clinical trial data suggest that the simple measurement of HDL-C may not be causal in preventing atherosclerosis nor reflect {HDL} functionality. Indeed, the measurement of HDL-C may be a biomarker of cardiovascular health. To assess the issue of {HDL} function as a potential therapeutic target, robust and simple analytical methods are required. The complex pleiotropic effects of {HDL} make the development of a single measurement challenging. Development of laboratory assays that accurately {HDL} function must be developed validated and brought to high-throughput for clinical purposes. This review discusses the limitations of current laboratory technologies for methods that separate and quantify {HDL} and potential application to predict CVD, with an emphasis on emergent approaches as potential biomarkers in clinical practice.
关键词：Atherosclerosis; Coronary artery disease; High density lipoproteins; Apolipoprotein A-I; Cellular cholesterol efflux; Vascular endothelial function; Biomarkers of cardiovascular risk
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