摘要:The analysis of the characteristics of Technology Transfer Offices (TTOs) is particularly important as they constitute mediating units in the relationship between the market and university research. They are responsible for the transfer and exploitation of knowledge arising in the university context. Previous studies have been inconclusive as to the importance that the size, professionalisation or age of TTOs might have on the transfer process. However, the need to explore new markets, recognise new opportunities and identify potential customers points to the importance of TTOs having a dual exploitative and exploratory orientation and an extensive relational network. More recent research in the literature, based on ambidexterity and network theory, points to the impact that these variables could have on change management and innovation in uncertain and changing environments, such as those faced by TTOs in the current pandemic context. Therefore, the aim of this paper is to analyse whether Spanish TTOs, due to their ambidextrous orientation at the organisational and individual level, and their relational network with academic and market actors, are prepared to promote innovation in a COVID-19 context. Based on a cluster analysis of 29 Spanish TTOs, our results show that just a few of the Spanish TTOs surveyed would be prepared, from the perspective of ambidexterity and their relational capital, to promote innovation in a COVID-19 context. In conclusion, Spanish TTOs and their employees should focus more on ambidexterity and building extensive relational capital so that, through mentoring, training, incubation or the provision of various resources, they can help academics take advantage of the innovation opportunities offered by the changing and uncertain environment.