摘要：High-grade gliomas are notorious for a high recurrence rate even after curative resection surgery. Studies regarding the influence of scalp block on high-grade gliomas have been inconclusive, possibly because the condition’s most important genetic mutation profile, namely the isocitrate dehydrogenase 1
(IDH1) mutation, had not been analyzed. Therefore, we conducted a single-center study including patients with high-grade glioma who underwent tumor resection between January 2014 and December 2019. Kaplan–Meier survival analysis revealed that scalp block was associated with longer progression-free survival (PFS; 15.17 vs. 10.77 months,
p = 0.0018), as was the
IDH1 mutation (37.37 vs. 10.90 months,
p = 0.0149). Multivariate Cox regression analysis revealed that scalp block (hazard ratio: 0.436, 95% confidence interval: 0.236–0.807,
p = 0.0082), gross total resection (hazard ratio: 0.405, 95% confidence interval: 0.227–0.721,
p = 0.0021), and
IDH1 mutation (hazard ratio: 0.304, 95% confidence interval: 0.118–0.784,
p = 0.0138) were associated with better PFS. Our results demonstrate that application of scalp block, regardless of
IDH1 profile, is an independent factor associated with longer PFS for patients with high-grade glioma.
