期刊名称：Current Journal of Applied Science and Technology
印刷版ISSN：2457-1024
出版年度：2021
卷号：40
期号：15
页码：54-60
DOI：10.9734/cjast/2021/v40i1531414
语种：English
出版社：Sciencedomain International
摘要：The goal of this research is to develop captopril mouth dissolving films and evaluate the impact of various formulation factors on the physical and mechanical properties of the films, as well as drug release behaviour. In different grades, hydroxypropyl methyl cellulose (HPMC E15 and K4M) was employed as the film forming polymer. Formulation disintegration times were determined to be in the range of (52 2.5 to 125.6 2.02 s). Formula F2 had the fastest disintegration time in vitro (52 2.5 s) and was determined to be acceptable for film production with ideal physicochemical qualities, faster disintegration, and optimal in vitro release. It may be concluded that the solvent casting approach can be used to make captopril mouth dissolving films with a higher dissolution rate and greater patient compliance.
关键词：Captopril;HPMC;disintegration time;mechanical properties;mouth dissolving film
