出版社：National Institute of Occupational Safety and Health
摘要：Previously, we reported that prenatal exposure to 1-bromopropane (1-BP) causes the accumulation of bromide (Br
-) in the brain of rat pups. Here, we aimed to investigate the effects of Br
- accumulation in rat pups prenatally exposed to 1-BP vapor. Dam rats were exposed to 1-BP (400 or 700 ppm; 1-BP group) by inhalation, or to NaBr (20 mM; Br
- group) in drinking water during gestation days 1–20. We also analyzed pentylenetetrazole (PTZ, 60 mg/kg, ip)-induced behavioral changes in pups prenatally exposed to 1-BP or Br
- on postnatal day (PND) 14. PTZ-induced epileptic convulsions were inhibited in both 1-BP (700 ppm) and Br
- groups. The inhibition of neuronal excitability induced by Br
- was evaluated electrophysiologically using the hippocampal slices obtained from PND14–16 pups. PTZ (2 mM) failed to induce epileptiform discharge in the presence of 1.2 mM Br
- in the slices obtained from the control group. However, it induced epileptiform discharge following the removal of Br
-, by perfusing artificial cerebrospinal fluid into the slices obtained from the Br
- group. Our results indicate that Br
- accumulates in the brain of neonatal rat pups prenatally exposed to 1-BP vapor suppressed neuronal excitability.
