摘要：Iron is a limiting factor in such a condition that usually is sequestered by the host during polymicrobial infections of
Pseudomonas aeruginosa and
Staphylococcus aureus. This study aimed to investigate the interaction of
S. aureus and
P. aeruginosa, which alters iron-related sigma factors regulation and antibiotic resistance. The antibiotic resistance of
P. aeruginosa and
S. aureus was investigated in a L929 cell culture model. The expression level of
pvdS,
hasI (
P. aeruginosa sigma factors), and
sigS (
S. aureus sigma factor) genes was determined using Quantitative Real-Time PCR.
pvdS and
hasI were downregulated during co-culture with
S. aureus, while the susceptibility to carbapenems increased (p-value < 0.0001). Also, there was a direct significant relationship between resistance to vancomycin with
sigS. Regarding the findings of the current study, iron-related sigma factors of
P. aeruginosa and
S. aureus play a role in induction susceptibility to various antibiotics, including carbapenems and vancomycin.
