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  • 标题:A novel antioxidant ergothioneine PET radioligand for in vivo imaging applications
  • 本地全文:下载
  • 作者:William J. Behof ; Clayton A. Whitmore ; Justin R. Haynes
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2021
  • 卷号:11
  • DOI:10.1038/s41598-021-97925-w
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:Ergothioneine (ERGO) is a rare amino acid mostly found in fungi, including mushrooms, with recognized antioxidant activity to protect tissues from damage by reactive oxygen species (ROS) components. Prior to this publication, the biodistribution of ERGO has been performed solely in vitro using extracted tissues. The aim of this study was to develop a feasible chemistry for the synthesis of an ERGO PET radioligand, [ 11C
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