文章基本信息
- 标题：Anti-aging properties of metformin
- 本地全文：下载
- 作者：Anna Małgorzata Łopuszyńska ; Mateusz Pawlicki ; Magdalena Kozioł 等
- 期刊名称：Journal of Education, Health and Sport
- 电子版ISSN：2391-8306
- 出版年度：2021
- 卷号：11
- 期号：9
- 页码：37-42
- DOI：10.12775/JEHS.2021.11.09.005
- 语种：English
- 出版社：Kazimierz Wielki University
- 摘要：<div class="OutlineElement Ltr BCX0 SCXW48609226"><p class="Paragraph SCXW48609226 BCX0"><span class="TextRun SCXW48609226 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">Introduction</span><span class="NormalTextRun SCXW48609226 BCX0">: </span><span class="NormalTextRun SCXW48609226 BCX0">L</span><span class="NormalTextRun SCXW48609226 BCX0">ife </span><span class="NormalTextRun SCXW48609226 BCX0">expectancy</span><span class="NormalTextRun SCXW48609226 BCX0"> of</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">human</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">population</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">is</span><span class="NormalTextRun SCXW48609226 BCX0"> </span></span><span class="TextRun SCXW48609226 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW48609226 BCX0">being </span><span class="NormalTextRun SCXW48609226 BCX0">constantly</span></span><span class="TextRun SCXW48609226 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="none"> </span><span class="TextRun SCXW48609226 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW48609226 BCX0">prolonged</span><span class="NormalTextRun SCXW48609226 BCX0">, </span><span class="NormalTextRun SCXW48609226 BCX0">hence</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">there</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">is</span><span class="NormalTextRun SCXW48609226 BCX0"> a lot of </span><span class="NormalTextRun SCXW48609226 BCX0">research</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">into</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">drug</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">that</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">will</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">prevent</span><span class="NormalTextRun SCXW48609226 BCX0"> the </span><span class="NormalTextRun SCXW48609226 BCX0">effects</span><span class="NormalTextRun SCXW48609226 BCX0"> of </span><span class="NormalTextRun SCXW48609226 BCX0">aging</span><span class="NormalTextRun SCXW48609226 BCX0">. </span><span class="NormalTextRun SCXW48609226 BCX0">There</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">are</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">many</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">reports</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">that</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">metformin</span><span class="NormalTextRun SCXW48609226 BCX0">, </span><span class="NormalTextRun SCXW48609226 BCX0">which</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">is</span><span class="NormalTextRun SCXW48609226 BCX0"> a </span><span class="NormalTextRun SCXW48609226 BCX0">drug</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">used</span><span class="NormalTextRun SCXW48609226 BCX0"> in </span><span class="NormalTextRun SCXW48609226 BCX0">type</span><span class="NormalTextRun SCXW48609226 BCX0"> 2 </span><span class="NormalTextRun SCXW48609226 BCX0">diabetes</span><span class="NormalTextRun SCXW48609226 BCX0">, </span><span class="NormalTextRun SCXW48609226 BCX0">has</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">anti-aging</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">effects</span><span class="NormalTextRun SCXW48609226 BCX0">.</span><span class="NormalTextRun SCXW48609226 BCX0"> It belongs to the group of biguanides and has been used since the 1950s. It is a relatively safe, cheap and effective drug, which makes it a promising subject for many studies.</span><span class="NormalTextRun SCXW48609226 BCX0"> The purpose of this review is to present the latest developments in this field.</span></span><span class="EOP SCXW48609226 BCX0" data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p></div><div class="OutlineElement Ltr BCX0 SCXW48609226"><p class="Paragraph SCXW48609226 BCX0"><span class="TextRun SCXW48609226 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW48609226 BCX0">Material</span><span class="NormalTextRun SCXW48609226 BCX0"> and </span><span class="NormalTextRun SCXW48609226 BCX0">methods</span><span class="NormalTextRun SCXW48609226 BCX0">:</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">PubMed</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">scientific</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">base</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="ContextualSpellingAndGrammarError SCXW48609226 BCX0">was</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">searched</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">using</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">following</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">keywords</span><span class="NormalTextRun SCXW48609226 BCX0">: </span><span class="NormalTextRun SCXW48609226 BCX0">metformin</span><span class="NormalTextRun SCXW48609226 BCX0">, </span><span class="NormalTextRun SCXW48609226 BCX0">aging</span><span class="NormalTextRun SCXW48609226 BCX0">, </span><span class="NormalTextRun SCXW48609226 BCX0">anti-aging</span><span class="NormalTextRun SCXW48609226 BCX0">, in</span><span class="NormalTextRun SCXW48609226 BCX0"> </span><span class="NormalTextRun SCXW48609226 BCX0">years</span><span class="NormalTextRun SCXW48609226 BCX0"> 2017-2021.</span></span><span class="EOP SCXW48609226 BCX0" data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p></div><div class="OutlineElement Ltr BCX0 SCXW48609226"><p class="Paragraph SCXW48609226 BCX0"><span class="TextRun SCXW48609226 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW48609226 BCX0">Results: Numerous studies show that metformin has an impact on aging through the nutrient pathway, AMPK signaling pathway, and</span><span class="NormalTextRun SCXW48609226 BCX0"> </span></span><span class="TextRun SCXW48609226 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW48609226 BCX0">its</span><span class="NormalTextRun SCXW48609226 BCX0"> e</span></span><span class="TextRun SCXW48609226 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW48609226 BCX0">ffects on reactive oxygen species. </span><span class="NormalTextRun SCXW48609226 BCX0">In addition, it has an anti-cancer effect, inhibiting, among others, rectal cancer cells and p53 mutant colon cancer. </span><span class="NormalTextRun SCXW48609226 BCX0">Research in rodents has shown that </span></span><span class="TextRun SCXW48609226 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW48609226 BCX0">th</span><span class="NormalTextRun SCXW48609226 BCX0">is</span></span><span class="TextRun SCXW48609226 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="none"> </span><span class="TextRun SCXW48609226 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto">drug has anti-aging effects on many organs, including the CNS, ovaries, prostate, heart muscle and skin.</span><span class="EOP SCXW48609226 BCX0" data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p></div><div class="OutlineElement Ltr BCX0 SCXW48609226"><p class="Paragraph SCXW48609226 BCX0"><span class="TextRun SCXW48609226 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW48609226 BCX0">Conclusions</span><span class="NormalTextRun SCXW48609226 BCX0">: </span><span class="NormalTextRun SCXW48609226 BCX0">Metformin, which is the most commonly used oral drug in type 2 diabetes, has many other mechanisms of action. Its anti-aging effect works on many organs in our bodies, which gives hope to find an anti-aging substance. However, </span><span class="SpellingError SCXW48609226 BCX0">multicentre</span><span class="NormalTextRun SCXW48609226 BCX0">, randomized trials are needed to determine the exact anti-aging dose, </span><span class="ContextualSpellingAndGrammarError SCXW48609226 BCX0">its</span><span class="NormalTextRun SCXW48609226 BCX0"> possible side effects, and effects on various organisms.</span></span><span class="EOP SCXW48609226 BCX0" data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p></div>
