摘要：<p dir="ltr">Introduction: Caffeine is considered to be one of the most frequently used pharmacologically active substances in the world. Caffeine is a psychoactive and central nervous system stimuli that has the ability to increase energy, decrease fatigue, promote alertness and wakefulness. Potential role of caffeine's nociceptive properties shows that it may play a relevant role in pain modulation. Although caffeine at dietary levels is not a sufficient analgesic in its own, it has been included in many over-the-counter and prescription drugs. This review addresses caffeine's analgesic properties in pain management. </p><span><span><br /></span></span><p dir="ltr"><span>Results:</span><span> Caffeine shows relevant </span><span>role in pain modulation through blocking adenosine receptors which are involved in nociception.</span><span> Studies show that </span><span>habitual dietary caffeine consumption results in decreased pain sensitivity.</span><span>As an adjuvant to commonly used analgesics, caffeine provides an important increase in pain relief in various types of pain such as postoperative dental pain, headaches, or fibromyalgia.</span></p><span><span><br /></span></span><p dir="ltr"><span>Conclusions:</span><span> In conclusion, caffeine is associated with </span><span>decreased pain sensitivity</span><span>. Addition of caffeine to analgesics has resulted in their enhanced analgesic efficacy in pain treatment.</span></p>
