期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2021
卷号：67
期号：4
页码：234-242
DOI：10.3177/jnsv.67.234
语种：English
出版社：Center for Academic Publications Japan
摘要：Docosahexaenoic acid (DHA) and lutein are important nutrients for brain health. Whether there were synergistic effects of DHA and lutein on the protection against neuronal cell damage induced by oxidative stress remained unclear. The present study was designed to investigate the synergistic effects of DHA and lutein against hydrogen peroxide (H2O2)-induced oxidative challenge in PC12 cells. PC12 cells were divided into different groups and received H2O2(80 μM), lutein (20 μM)+H2O2(80 μM), DHA (25 μM)+H2O2(80 μM), and lutein (20 μM)+DHA (25 μM)+H2O2(80 μM), respectively. The results indicated that pre-treatment of cells with lutein, DHA and DHA+lutein could significantly antagonize the H2O2-mediated growth inhibition and morphological changes in PC12 cells (p
