摘要：We examined associations between cognition and mortality and how these relationships vary by race and Apolipoprotein E (
APOE) genotype, in a longitudinal study of 2346 middle-aged White and African American adults (30–64 years at baseline) from the Healthy Aging in Neighborhoods of Diversity across the Life Span cohort study. Baseline cognition spanned global mental status, and several domains obtained using principal components analysis (PCA; PCA1: verbal memory/fluency; PCA2: attention/working memory; PCA3: executive function/visuo-spatial abilities). Cox regression models evaluated associations between cognition and all-cause and cardiovascular disease (CVD)-mortality. Interactions between cognition and
APOE2 as well as
APOE4 allelic dose were tested, and race was a key effect modifier. Higher
APOE4 dose was associated with increased CVD-mortality (hazard ratio [HR
