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  • 标题:A small molecule screen identifies novel inhibitors of mechanosensory nematocyst discharge in Hydra
  • 本地全文:下载
  • 作者:Diana Hofmann ; Niharika Garg ; Simone Grässle
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2021
  • 卷号:11
  • DOI:10.1038/s41598-021-99974-7
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:Cnidarians are characterized by the possession of stinging organelles, called nematocysts, which they use for prey capture and defense. Nematocyst discharge is controlled by a mechanosensory apparatus with analogies to vertebrate hair cells. Members of the transient receptor potential (TRPN) ion channel family are supposed to be involved in the transduction of the mechanical stimulus. A small molecule screen was performed to identify compounds that affect nematocyst discharge in Hydra. We identified several [2.2
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