摘要：In this study, we investigated the utility of native
T
1 mapping in differentiating between various grades of fibrosis and compared its diagnostic accuracy to magnetization transfer imaging (MTI) in a rat model of CD. Bowel specimens (64) from 46 CD model rats undergoing native
T
1 mapping and MTI were enrolled. The longitudinal relaxation time (
T
1 value) and normalized magnetization transfer ratio (MTR) were compared between none-to-mild and moderate-to-severe fibrotic bowel walls confirmed by pathological assessments. The results showed that the correlation between the
T
1 value and fibrosis (
r = 0.438,
p < 0.001) was lower than that between the normalized MTR and fibrosis (
r = 0.623,
p < 0.001). Overall, the
T
1 values (
t = −3.066,
p = 0.004) and normalized MTRs (
z = 0.081,
p < 0.001) in none-to-mild fibrotic bowel walls were lower than those in moderate-to-severe fibrotic bowel walls. The area under the curve (AUC) of the
T
1 value (AUC = 0.716,
p = 0.004) was significantly lower than that of the normalized MTR (AUC = 0.881,
p < 0.001) in differentiating moderate-to-severe fibrosis from none-to-mild fibrosis (
z = −2.037,
p = 0.042). Our results support the view that the
T
1 value could be a promising imaging biomarker in grading the fibrosis severity of CD. However, the diagnostic performance of native
T
1 mapping was not superior to MTI.
关键词：enCrohn’s disease;fibrosis;T1mapping;magnetization transfer imaging
