摘要：The correlation between copy number variation (CNV) and the susceptibility to systemic lupus erythematosus (SLE) has been reported for various immunity-related genes. However, the contribution of CNVs to SLE susceptibility awaits more investigation. To evaluate the copy numbers in immunity-related genes such as
TNFAIP3,
TNIP1,
IL12B,
TBX21 (
T-bet),
TLR7,
C4A,
C4B,
CCL3L1, and
CCL3L3, the modified real competitive polymerase chain reaction (mrcPCR) assay was employed, and the association between the copy numbers and SLE susceptibility was analyzed in 334 SLE patients and 338 controls.
CCL3L3-null status was significantly associated with SLE susceptibility (OR > 18,
P < 0.0001), which remained significant by Bonferroni’s correction (corrected
P = 0.0007). However, the significant association between
C4B low-copy status and SLE susceptibility (OR = 1.6051,
P = 0.0331) became non-significant by Bonferroni’s correction (corrected
P = 0.3938). Except for these results, no other significant association between SLE susceptibility and copy number status in other genes was observed. The
CCL3L3-null status may be a significant factor for SLE susceptibility.
