摘要：The aim of the study was to determine the drug resistance profile and to assess the presence of genes responsible for the production of extended-spectrum beta-lactamases in <i>Escherichia coli</i> isolated from energy-processed hop sediment with the addition of bulking agents. Antibiotic resistance was determined by the disk diffusion method and the PCR technique to detect genes determining the extended-spectrum beta-lactamases (ESBLs) mechanism. A total of 100 strains of <i>E. coli</i> were collected. The highest resistance was found to aztreonam, tetracycline, ampicillin, ticarcillin, and ceftazidime. The bacteria collected were most often resistant to even 10 antibiotics at the same time and 15 MDR strains were found. The ESBL mechanism was determined in 14 isolates. Among the studied genes responsible for beta-lactamase production, <i>blaTEM</i> was the most common (64%). The study revealed that the analysed material was colonised by multi-drug-resistant strains of <i>E. coli</i>, which pose a threat to public health. The obtained results encourage further studies to monitor the spread of drug resistance in <i>E. coli</i>.
