摘要:The COVID-19 epidemic caught governments and health authorities off guard and found them unprepared to face its impact on the world population. Italy was the second country after China to face the outbreak of COVID-19 in the first few months of 2020 and the northern part of the country was hit first and most heavily. Following the JD-R theory, an online survey was administered to investigate which specific risk and protective factors predicted depression in a heterogeneous sample of workers. The analyses (analysis of variance, correlations, multiple linear regressions) were run in the total sample and in the sample split by possibility of remote working. The sample consists of 301 workers in northern Italy, 65.1% being women, and a mean age of 42 years. Depression levels were higher in women and in those who were not able to work remotely. In the total sample, emotional exhaustion at work, sleep–wake cycle problems, and longing for touch were significant predictors of depression. The sample split by the possibility of remote working also showed interesting differences. The results show the importance of monitoring the mental health of workers from professional contexts that are currently less widely studied than the healthcare sector, with particular interest in the possibility of remote working.