摘要：Abstract Introduction In {PKU} there is little data comparing the prevalence of overweight and obesity in different countries. The aim of this cross sectional study was to evaluate prevalence data from different {PKU} treatment centres in Europe and Turkey. Subjects and methods In children, body mass index (BMI) and z scores and in adults {BMI} were calculated in 947 patients (783 children aged < 19 years; 164 adults aged ≥ 19 years) with {PKU} from centres in Europe and Turkey (Ankara, Birmingham, Brussels, Copenhagen, Groningen, Madrid, Munich and Porto). Results In adults with PKU, 83% of centres (n = 5/6) had less overweight than the general populations but 83% (n = 5/6) had a higher rate of female obesity. In childhood, all centres reported obesity rates within or similar to local population ranges in boys but in 57% (n = 4/7) of centres a higher rate of obesity in girls. The percentage of overweight and obesity increased with age. Discussion In PKU, it is clear from a number of treatment centres that women and girls with {PKU} appear particularly vulnerable to excess weight gain and it is important that female weight gain is closely monitored and individual strategies introduced to prevent excess weight gain. Overall, in {PKU} there is a need to understand better the food patterns and activity levels of patients.
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