摘要：SummaryThe gut microbiome has emerged as a key regulator of obesity; however, its role in brown adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We found that the levels of circulating branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) were significantly correlated with the body weight in humans and mice and that BCAA catabolic defects in BAT were associated with obesity in diet-induced obesity (DIO) mice. Pharmacological systemic enhancement of BCAA catabolic activity reduced plasma BCAA and BCKA levels and protected against obesity; these effects were reduced in BATectomized mice. DIO mice gavaged withBacteroides doreiandBacteroides vulgatusexhibited improved BAT BCAA catabolism and attenuated body weight gain, which were not observed in BATectomized DIO mice. Our data have highlighted a possible link between the gut microbiota and BAT BCAA catabolism and suggest thatBacteroidesprobiotics could be used for treating obesity.Graphical abstractDisplay OmittedHighlights•Gut microbiota regulated BAT BCAA catabolism•Bacteroidespromoted BAT BCAA catabolism and inhibited obesity•Bacteroidessuppressed BAT inflammation that contributed to BAT BCAA catabolic defectComputer systems organization; Energy engineering; Energy systems
