摘要：SummaryChemotaxis is ubiquitous in many biological processes, but it still remains elusive how cells sense and decipher multiple chemical cues. In this study, we postulate a hypothesis that the chemotactic performance of cells under complex cues is regulated by the signal processing capacity of the cellular sensory machinery. The underlying rationale is that cellsin vivoshould be able to sense and process multiple chemical cues, whose magnitude and compositions are entangled, to determine their migration direction. We experimentally show that the combination of transforming growth factor-β and epidermal growth factor suppresses the chemotactic performance of cancer cells using independent receptors to sense the two cues. Based on this observation, we develop a biophysical framework suggesting that the antagonism is caused by the saturation of the signal processing capacity but not by the mutual repression. Our framework suggests the significance of the signal processing capacity in the cellular sensory machinery.Graphical abstractDisplay OmittedHighlights•Cellular sensory machinery can sense and decipher multiple chemical cues simultaneously•Combination of TGF-β and EGF suppresses the chemotactic accuracy of cancer cells•Cells have the physical capacity in signal processing with the shared pathway•The saturation of the shared pathway can disturb the cells' accurate chemotaxisCell biology; Mathematical biosciences; Systems biology
