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  • 标题:Adipose MDM2 regulates systemic insulin sensitivity
  • 本地全文:下载
  • 作者:Philip Hallenborg ; Benjamin Anderschou Holbech Jensen ; Even Fjære
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2021
  • 卷号:11
  • DOI:10.1038/s41598-021-01240-3
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in their adipose stores suffer from overt obesity, glucose intolerance, and hepatic steatosis. These mice had decreased levels of circulating palmitoleic acid [non-esterified fatty acid (NEFA) 16:1
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