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  • 标题:The first observation of osmotically neutral sodium accumulation in the myocardial interstitium
  • 本地全文:下载
  • 作者:I. Artyukov ; G. Arutyunov ; M. Bobrov
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2021
  • 卷号:11
  • DOI:10.1038/s41598-021-01443-8
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:The aim of this study was the detection and quantification of the Na + depositions in the extracellular matrix of myocardial tissue, which are suggested to be bound by negatively charged glycosaminoglycan (GAG) structures. The presented experimental results are based on high resolution X-ray fluorescence (XRF) spectromicroscopy technique used to perform a comparative analysis of sodium containment in intracellular and interstitial spaces of cardiac tissues taken from animals selected by low and high sodium intake rates. The experimental results obtained show that high sodium daily intake can result in a remarkable increase of sodium content in the myocardial interstitium.
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