标题：Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial
摘要：Background
The dietary spice
Curcuma longa, also known as turmeric, has various biological effects. Both a water extract and a supercritical carbon dioxide extract of
C. longa showed anti-inflammatory activities in animal studies. However, the anti-inflammatory effect in humans of a mixture of these two
C. longa extracts (CLE) is poorly understood. Therefore, we investigated the effect of CLE containing anti-inflammatory turmeronols on chronic inflammation and general health.
Methods
We performed a randomized, double-blind, placebo-controlled study in healthy subjects aged 50 to 69 years with overweight. Participants took two capsules containing CLE (CLE group,
n = 45) or two placebo capsules (placebo group, n = 45) daily for 12 weeks, and serum inflammatory markers were measured. Participants also completed two questionnaires: the Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF-36) and the Profile of Mood States (POMS) scale. Treatment effects were analyzed by two way analysis of variance followed by a
t test (significance level,
p < 0.05).
Results
After the intervention, the CLE group had a significantly lower body weight (p < 0.05) and body mass index (
p < 0.05) than the placebo group and significantly lower serum levels of C-reactive protein (
p < 0.05) and complement component 3 (
p < 0.05). In addition, the CLE group showed significant improvement of the MOS SF-36 mental health score (
p < 0.05) and POMS anger-hostility score (p < 0.05).
Conclusion
CLE may ameliorate chronic low-grade inflammation and thus help to improve mental health and mood disturbance.
Trial registration
UMIN-CTR, UMIN000037370. Registered 14 July 2019,
https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000042607
Supplementary Information
The online version contains supplementary material available at 10.1186/s12937-021-00748-8.
关键词：Turmeric (Curcuma longa); Bisacurone; Body mass index (BMI); Turmeronol; Chronic inflammation; C-reactive protein (CRP); Complement component 3 (C3); 36-item short-form health survey (SF-36); Profile of mood states (POMS)
