摘要：BOWEN'S DISEASE (BD) IS AN IN SITU, PREINVASIVE CANCER WITH POTENTIAL FOR PROGRESSION IN SQUAMOUS CELL CARCINOMA (SCC), BEING CLINICALLY CONSIDERED A PRECANCER WITH A HIGH POTENTIAL FOR MALIGNANCY.THE AIMS OF THE STUDY WERE TO ASSESS THE CLINICAL, HISTOLOGICAL, AND EVOLUTIONARY ASPECTS OF THE BOWEN'S DISEASE AND INVASIVE BOWEN DISEASE.THE STUDIED GROUP COMPRISES 50 PATIENTS DIAGNOSED WITH BOWEN DISEASE OR INVASIVE BD, HOSPITALIZED IN THE DERMATOLOGY CLINIC OF EMERGENCY COUNTY HOSPITAL OF CRAIOVA, BETWEEN 2010 AND MARCH 2021. THERE WERE 18 MALES AND 32 FEMALES, AGED 30 TO 85 YEARS, 66% OF THE PATIENTS BEING FROM THE URBAN ENVIRONMENT. THE MOST FREQUENT LOCALIZATION OF BD WAS AT THE LEVEL OF THE LIMBS (52%), ON PHOTOEXPOSED AREAS. IN 92% OF CASES, WE NOTICED CLINICAL ASPECT OF BD WITH SINGLE LESIONS AND THE TYPICAL FORM WAS PREDOMINANCE (80%).THE PATHOLOGY DIAGNOSED 41 BD AND 9 INVASIVE BD (SQUAMOUS CELL CARCINOMA). PRESUMPTIVE CLINICAL DIAGNOSIS IN 31 CASES (57.40%), WAS CONFIRMED BY HISTOPATHOLOGICAL EXAMINATION.THE CORRELATION OF CLINICAL, HISTOPATHOLOGICAL DATA LEAD TO AN ACCURATE DIAGNOSIS OF BD. BOWEN'S DISEASE, ALONG WITH OTHER KERATINOCYTIC PRECANCERS, BEING A STRONG PREDICTOR OF THE RISK OF DEVELOPING SKIN CARCINOMAS AND MELANOMA, REQUIRING A PROMPT THERAPEUTIC ATTITUDE AND CAREFUL MONITORING.
