标题：Levels of Hippocampal, Liver, and Plasma Insulin-like Growth Factor 1 (IGF-1) in Male Adult Rats Treated with Combination of Aerobic Exercise and Continuous Environmental Enrichment
摘要：Yolanda S, Mailani R, Prasety SR, Widyani NMS, Juffry SK.Levels of Hippocampal, Liver, and Plasma Insulin-like Growth Factor1 (IGF-1) in Male Adult Rats Treated with Combination of AerobicExercise and Continuous Environmental Enrichment. JEPonline2019;22(1):11-20. The purpose of this study was to determine theeffect of the combination treatment of both aerobic exercise andenvironmental enrichment (EE) on the levels of hippocampal, liver,and plasma Insulin-like growth factor 1 (IGF- 1). IGF-1 has beenrecently shown to play a role in neuroplasticity including memoryfunction. Both aerobic exercise and EE on their own have beenproven to increase neuroplasticity. Twenty 7-month-old male Wistarrats were divided randomly into 4 groups: (a) control (C); (b) aerobic(A); (c) environmental enrichment (EE); and (d) combination ofaerobic exercise and EE (A-EE) for 8 wks. There were no significantdifferences in the plasma and hippocampal IGF-1 levels between thegroups (P = 0.65 and P = 0.13, respectively). There were significantdifferences in the liver IGF-1 levels between the A and the EEgroups (P = 0.013) and between the A and the A-EE groups (P =0.02). No increase of IGF-1 level in rats treated with a combinationof aerobic exercise and continuous EE may be due to IGF-1’s nonneural expression in the periphery and its synergistic effect withother growth factors.
