摘要：Summary Circulating mesenchymal stem cells (MSCs) is a new cell source for tissue regeneration and tissue engineering. The characteristics of circulating {MSCs} are similar to those of bone marrow-derived {MSCs} (BM-MSCs), but they exist at a very low level in healthy individuals. It has been demonstrated that {MSCs} are able to migrate to the sites of injury and that they have some distinct genetic profiles compared to BM-MSCs. The current review summaries the basic knowledge of circulating {MSCs} and their potential clinical applications, such as mobilizing the BM-MSCs into circulation for therapy. The application of {MSCs} to cure a broad spectrum of diseases is promising, such as spinal cord injury, cardiovascular repair, bone and cartilage repair. The current review also discusses the issues of using of allogeneic {MSCs} for clinical therapy.
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