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  • 标题:Open-source hybrid 3D-bioprinter for simultaneous printing of thermoplastics and hydrogels
  • 本地全文:下载
  • 作者:Fritz Koch ; Fritz Koch ; Ole Thaden
  • 期刊名称:OpenHardwareX
  • 印刷版ISSN:2468-0672
  • 出版年度:2021
  • 卷号:10
  • 页码:1-20
  • DOI:10.1016/j.ohx.2021.e00230
  • 语种:English
  • 出版社:Elsevier
  • 摘要:Graphical abstractDisplay OmittedAbstract3D-bioprinting is a promising technology applicable in areas such as regenerative medicine orin vitroorgan model development. Various 3D-bioprinting technologies and systems have been developed and are partly commercially available. Here, we present the construction and characterization of an open-source low-cost 3D-bioprinter that allows the alternated microextrusion of hydrogel and fused deposition modeling (FDM) of thermoplastic filaments.The presented 3D-bioprinter is based on a conventional Prusa i3 MK3 printer and features two independent printheads: the original FDM-head and a syringe-based microextrusion printhead for soft materials. Modifications were designed modularly to fit various syringe formats or heating elements to the device. The bioprinter is the first hybrid DIY 3D-bioprinter that allows switching between materials as often as required during a print run to produce complex multi-material constructs with arbitrary patterns in each layer.For validation of the printer, two designs suitable for relevant bioprinting applications were realized. First, a porous plastic construct filled with hydrogel was printed, serving as a mechanically stable bone replacement tissue model. Second, a plastic chamber, which might be used in organ-on-a-chip applications, was printed with an extruded silicone sealing that enables the liquid-tight attachment of glass slides to the top and bottom of the chamber.
  • 关键词:Hybrid printing;3D-Bioprinting;Open-source;Rapid prototyping;Hydrogel extruder;3D- printer
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