文章基本信息

标题：Comparative Study of Hugel-tox® versus Botox® for the Treatment of Essential Blepharospasm
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作者：Lee, Jee Hye ; Jung, Su Kyung ; Baik, Ji Sun 等
期刊名称：Journal of the Korean Ophthalmological Society
印刷版ISSN：0378-6471
出版年度：2015
卷号：56
期号：6
页码：811-814
DOI：10.3341/jkos.2015.56.6.811
语种：Korean
出版社：The Korean Ophthalmological Society
摘要：Purpose
To compare clinical efficacy and duration of Hugel-tox® (also known as Botulax®) and Botox® for the treatment of essential blepharospasm.
Methods
A total of 48 patients who were injected with Hugel-tox® (17 females, 7 males) or Botox® (18 females, 6 males) from February 2013 to October 2013 were enrolled in the present study. Changes in eyelid closing force and Scott grade before and after injection were analyzed. Adverse events were also evaluated.
Results
There were no significant differences between the Hugel-tox® and Botox® groups in clinical efficacy and duration. Before and after injection, changes in Scott grade (Hugel-tox®: -1.17 ± 0.70, Botox®: -1.21 ± 0.72, p = 0.840), changes in eyelid closing force (Hugel-tox®: -1.38 ± 0.58, Botox®: -1.17 ± 0.56, p = 0.212) and duration (Hugel-tox®: 116.08 ± 22.12 days, Botox®: 126.92 ± 38.94 days, p = 0.242) were shown. No serious adverse events were found in either group.
Conclusions
Hugel-tox® showed nearly equal efficacy and duration compared with Botox®.
关键词：Botox; Essential blepharospasm; Hugel-tox