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  • 标题:Design, synthesis, and biological evaluation of novel urolithins derivatives as potential phosphodiesterase II inhibitors
  • 本地全文:下载
  • 作者:Long Tang ; Jianchun Jiang ; Guoqiang Song
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2021
  • 卷号:11
  • DOI:10.1038/s41598-021-03194-y
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:A series of urolithins derivatives were designed and synthesized, and their structures have been confirmed by 1H NMR, 13C NMR, and HR-MS. The inhibitory activity of these derivatives on phosphodiesterase II (PDE2) was thoroughly studied with 3-hydroxy-8-methyl-6 H-benzo[C
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